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AHCC protocol 01
Randomised trial of high-dose tamoxifen versus placebo in the treatment of inoperable hepatocellular carcinoma.
Status
completed in June 2000 with recruitment of 324 patients. Results published in Hepatology 2002 36:1221-1226
Contributing Principal Investigators and Centres
Khin Maung Win (Myanmar), Phillip Johnson (Hong Kong), Soo Khee Chee (Singapore), Tan Chee Kiat (Singapore), T Manuaba (Indonesia), Thiravud Khuhaprema (Thailand), A Haron (Malaysia), SH Bae (South Korea), J Cebon (Australia), M Findlay (New Zealand)
Clinical coordinator Pierce Chow
gsupc@singnet.com.sg
AHCC protocol 02
Randomised trial of megestrol acetate versus placebo in the treatment of inoperable hepatocellular carcinoma.
Status Closed. Results undergoing analysis.
Planned sample size of 300 patients
Contributing Principal Investigators and Centres
Khin Maung Win (Myanmar), Soo Khee Chee (Singapore), Hoang Hoa Hai (Ho Chi Min City, Vietnam), Nguyen Ba Duc (Hanoi, Vietnam), Jin Mo-Yang (south Korea), R Lobo (Phillipines), M Ishaque (Bangladesh), M Findlay (New Zealand)
Clinical coordinator Pierce Chow
gsupc@singnet.com.sg
AHCC protocol 03
Randomised trial of adjuvant intra-arterial radio-active iodine after curative resection of hepatocellular carcinoma.
Status Closed. Results undergoing analysis.
Planned sample size of 200
Contributing Principal Investigators and Centres
Lucien Ooi (NCC, Singapore), Tay Khoon Hean (Changi General Hospital, Singapore), Chew Soo Ping (Tan Tock Seng Hospital, Singapore)
Clinical coordinator

Alex Chung
gsucyf@sgh.com.sg

AHCC protocol 04
Dose escalating trial of intra-tumoral BrachySil in unresectable hepatocellular carcinoma.
Status Closed.
Planned sample size of 50
Contributing Principal Investigators and Centres
Pierce Chow, Anthony Goh (SGH, Singapore), Richard Guan (Mt Elizabeth Hospital, Singapore) Foo Kian Fong, Susan Loong (NCC, Singapore), Liau Kui Hin (TTSH, Singapore), Hoang Hoa Hai (Choray Hospital, Ho Chi Min City), Harjit Singh (Selayang Hospital, Kuala Lumpur)
Clinical coordinator Pierce Chow
gsupc@singnet.com.sg
AHCC protocol 05
Phase I/II Study of SIR-Spheres plus Sorafenib (Chemo-Radiotherapy) as first line treatment in patients with non-resectable primary hepatocellular carcinoma.
Status Recruiting in June 2008.
Planned sample size of 31 patients.
Contributing Principal Investigators and Centres
Pierce Chow, Anthony Goh (SGH, Singapore), Soo Khee Chee (NCC, Singapore), Tan Say Beng (CTERU, Singapore), Lai Hee Kit (SGH, Singapore), Tay Kiang Hiong (SGH, Singapore), Richard Hoau Gong Lo (SGH, Singapore), Donald Poon Yee Hee (NCC, Singapore)
Clinical coordinator Pierce Chow
gsupc@singnet.com.sg


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